One of the most curious bugs I ever came across was found deep inside a third-party JavaScript grid component. This grid component had a fixed height and width. It calculated column widths by taking the total grid width and distributing it to the different columns, each of which got a certain, predefined percentage.
On Mac OS X, everything looked nice. But on Windows, the column headers were oddly shifted and did not match the content columns. While investigating the bug, we found out that the columns were shifted by exactly 17 pixels to the left. But why 17 pixels? And not 5, 10, 15 or anything power of 2?